SAFETY AND EFFICACY OF THE INTRAVENOUS INFUSION OF UMBILICAL CORD MESENCHYMAL STEM CELLS IN PATIENTS WITH HEART FAILURE A PHASE 1/2 RANDOMIZED CONTROLLED TRIAL
ABSTRACTUmbilical cord–derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow–derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has […]
IMPROVEMENT OF RENAL FUNCTION AFTER HUMAN UMBILICAL CORD MESENCHYMAL STEM CELL TREATMENT ON CHRONIC RENAL FAILURE AND THORACIC SPINAL CORD ENTRAPMENT: A CASE REPORT
1️⃣ Human umbilical cordmesenchymal stem cells are immune naïve and they are able to differentiate into other phenotypes, including the neural lineage. Over the past decade, advances in the field of regenerative medicine allowed development of cell therapies suitable for kidney repair. 2️⃣ We report a case of a 62-year-old ethnic Indonesian woman previously diagnosed […]
Treatment with human umbilical cord-1 derived mesenchymal stem cells for COVID-19 patients with lung damage: a randomised, double-blind, placebo-controlled phase 2 trial
1️⃣ Treatment of severe Corona Virus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe COVID-19 patients with lung damage, based on our phase 1 data. 2️⃣ UC-MSCs treatment is a safe and potentially effective therapeutic approach […]
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
1️⃣ Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement in focal or diffuse disease. 2️⃣This study aimed to assess the safety and efficacy of the intra-articular injection of single […]
Covid-19 Patient treated by Human Umbilical Cord Mesenchymal Stem Cells
1️⃣ The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown very good capability to modulate immune response and repair the injured tissue with good safety. 2️⃣ The Significant clinical outcome and well tolerance was observed by the adoptive transfer of allogenic hUCMSCs. 3️⃣ The human umbilical cord mesenchymal stem cells (hUCMSCs) was also suggested […]