THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS FOR DIABETES
ABSTRACTMesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative […]
SAFETY AND EFFICACY OF THE INTRAVENOUS INFUSION OF UMBILICAL CORD MESENCHYMAL STEM CELLS IN PATIENTS WITH HEART FAILURE A PHASE 1/2 RANDOMIZED CONTROLLED TRIAL
ABSTRACTUmbilical cord–derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow–derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has […]
THE CLINICAL APPLICATION OF MESENCHYMAL STEM CELLS IN LIVER DISEASE: THE CURRENT SITUATION AND POTENTIAL FUTURE
1️⃣ UC-MSC can be obtained free and amplify to a large number. It has been reported that UC-MSC transplantation alleviate symptoms of various autoimmune diseases. 2️⃣ UC-MSCs show a more beneficial immunogenic profile and stronger overall immunosuppressive potential than BM-MSCs. 3️⃣ After UC-MSC therapy, liver function was improved, that serum albumin levels increased and bilirubin […]