1️⃣ Directed CM differentiation of human-induced pluripotent stem cells (hiPSCs) employs systematic biochemical treatments to streamline definitive stages of cardiac development, generating spontaneously contracting cardiomyocytes (CMs) at high efficiency in vitro.

2️⃣ The use of hiPSC-derived CMs may have broad therapeutic applications in cardiac cellular therapy, myocardial tissue engineering, disease modeling, and drug screening for treating the failing heart.

3️⃣ Studies have shown that the combination of CMs with non-myocyte cardiovascular cells such as fibroblasts, endothelial cells, and smooth muscle cells can enhance morphological and functional maturity.

Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

[By Celebre Pro Medic Sdn Bhd 20211217]

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