THE BENEFITS OF WHOLE-GENOME SEQUENCING NOW AND IN THE FUTURE

1️⃣ Our knowledge of all the strong signals in the human genome is in fact increasing steadily. As a consequence of the continuing new discoveries, although a person’s genome may not reveal obvious strong signals on first analysis, part of the value of genomics is that data can be stored and analyzed as knowledge accrues, […]

WHOLE GENOME SEQUENCING IN THE CLINIC: EMPOWERMENT OR TOO MUCH INFORMATION?

1️⃣ Next-generation sequencing encompasses several approaches: whole genome sequencing, whole exome sequencing and targeted sequencing.3–5 Whole genome sequencing reports all nucleotidebases in the entire genome, whole exome sequencing reports only the protein-coding regions (exons), and simpler targeted panels use next-generation sequencing chemistry to slice out information on predetermined disease-associated genes. 2️⃣ The hundreds of thousands […]

THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS FOR DIABETES

ABSTRACTMesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative […]

SAFETY AND EFFICACY OF THE INTRAVENOUS INFUSION OF UMBILICAL CORD MESENCHYMAL STEM CELLS IN PATIENTS WITH HEART FAILURE A PHASE 1/2 RANDOMIZED CONTROLLED TRIAL

ABSTRACTUmbilical cord–derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. Although bone marrow–derived mesenchymal stem cells have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction, no clinical trial has […]

THE CLINICAL APPLICATION OF MESENCHYMAL STEM CELLS IN LIVER DISEASE: THE CURRENT SITUATION AND POTENTIAL FUTURE

1️⃣ UC-MSC can be obtained free and amplify to a large number. It has been reported that UC-MSC transplantation alleviate symptoms of various autoimmune diseases. 2️⃣ UC-MSCs show a more beneficial immunogenic profile and stronger overall immunosuppressive potential than BM-MSCs. 3️⃣ After UC-MSC therapy, liver function was improved, that serum albumin levels increased and bilirubin […]

IMPROVEMENT OF RENAL FUNCTION AFTER HUMAN UMBILICAL CORD MESENCHYMAL STEM CELL TREATMENT ON CHRONIC RENAL FAILURE AND THORACIC SPINAL CORD ENTRAPMENT: A CASE REPORT

1️⃣ Human umbilical cordmesenchymal stem cells are immune naïve and they are able to differentiate into other phenotypes, including the neural lineage. Over the past decade, advances in the field of regenerative medicine allowed development of cell therapies suitable for kidney repair. 2️⃣ We report a case of a 62-year-old ethnic Indonesian woman previously diagnosed […]

Treatment with human umbilical cord-1 derived mesenchymal stem cells for COVID-19 patients with lung damage: a randomised, double-blind, placebo-controlled phase 2 trial

1️⃣ Treatment of severe Corona Virus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe COVID-19 patients with lung damage, based on our phase 1 data. 2️⃣ UC-MSCs treatment is a safe and potentially effective therapeutic approach […]

HUMAN IPS-DERIVED PRE-EPICARDIAL CELLS DIRECT CARDIOMYOCYTE AGGREGATION EXPANSION AND ORGANIZATION IN VITRO

1️⃣ Directed CM differentiation of human-induced pluripotent stem cells (hiPSCs) employs systematic biochemical treatments to streamline definitive stages of cardiac development, generating spontaneously contracting cardiomyocytes (CMs) at high efficiency in vitro. 2️⃣ The use of hiPSC-derived CMs may have broad therapeutic applications in cardiac cellular therapy, myocardial tissue engineering, disease modeling, and drug screening for […]

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

1️⃣ Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement in focal or diffuse disease. 2️⃣This study aimed to assess the safety and efficacy of the intra-articular injection of single […]